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Thursday, August 6, 2020 | History

2 edition of synthesis of nucleoside and nucleotide analogues as potential antiviral agents found in the catalog.

synthesis of nucleoside and nucleotide analogues as potential antiviral agents

Shin-Ichiro Shimizu

synthesis of nucleoside and nucleotide analogues as potential antiviral agents

by Shin-Ichiro Shimizu

  • 141 Want to read
  • 12 Currently reading

Published by University of Birmingham in Birmingham .
Written in English


Edition Notes

Thesis (Ph.D)-University of Birmingham, School of Chemistry.

Statementby Shin-Ichiro Shimizu.
ID Numbers
Open LibraryOL13929265M

Herein, we discuss recent advances in the chemical synthesis and biological evaluation of nucleoside analogues as potential anticancer agents. Focus is paid to 4′-heteroatom substitution of the furanose oxygen, 2′-, 3′-, 4′- and 5′-position ring modifications and the development of . In general, nucleoside and nucleotide analogues target key biological pathways in the replication cycles of many diseases; However, some have also been shown to target human enzymes, which can sometimes result in deleterious consequences. In this regard, the primary issue with this class of drugs involves selectivity.

This is regarded as a novel antiviral mechanism of action, reducing crossresistance to other existing anti-influenza drugs. Objective: To develop new analogs, a class of 1,3-oxathiolane nucleoside derivatives of T was designed and synthesized in this work. Results: Anti-influenza activity and Anti-HIV activity of these compounds were evaluated.   Drugs such as acyclovir, are nucleoside analogues that lack a free 3′ group that is needed for the addition of the next nucleotide. When added into a growing DNA chain they stop its synthesis. Another drug, foscarnet, mimics pyrophosphates and inactivates the .

  This book examines the structural components of NTPs' diverse biological properties and therapeutic consequences, including cytotoxic compounds, antiviral agents, and immunosuppressive molecules. The text describes synthetic methods used for all types of nucleotides and reviews families of enzymes that depend on nucleotides for assembling DNA and RNA s: 3. Cytotoxic nucleoside analogues and nucleobases were among the first chemotherapeutic agents to be introduced for the medical treatment of cancer. This family of compounds has grown to include a variety of purine and pyrimidine nucleoside derivatives with activity in both solid tumours and malignant disorders of the blood. These agents behave as antimetabolites, compete with physiological.


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Synthesis of nucleoside and nucleotide analogues as potential antiviral agents by Shin-Ichiro Shimizu Download PDF EPUB FB2

Some of the uridine analogues listed above have been previously shown to be substrates of viral polymerases (Arup et al., ; Lauridsen et al., ).The 2′-O-methyluridine triphosphate is of particular interest since 2′-O-methyl nucleotides can resist removal by the 3′-exonuclease found in coronaviruses (Minskaia et al., ).We describe the properties of 5 nucleotide analogues whose Cited by: 3.

The nucleoside and prodrug forms for the FDA approved drugs are shown in Fig. 2, and nucleoside and potential prodrug forms for three of the others are shown in Fig. Some of the uridine analogues listed above have been investigated as inhibitors of viral polymerases (Kumaki et al.

; Eyer et al. ; Arup et al. ; Lauridsen et al Cited by: 1. Compiles current tested and proven approaches to synthesize novel nucleoside analogues Featuring contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues.

By Andrew Neiderman - design synthesis and antiviral activity of nucleoside and nucleotide analogues victor e marquez chapter 10 doi bk ch publication date print august 22 structure activity investigation in the series of acyclic nucleotide analogs bearing a modified.

Design and Synthesis of Novel 1′,3′-Dioxolane 5′-Deoxyphosphonic Acid Purine Analogues as Potent Antiviral Agents.

Nucleosides, Nucleotides and Nucleic Acids31 (2), nucleotide analogues as antiviral agents5 we have undertaken the synthesis of compound 3 famciclovir is the oral form of penciclovir a highly selective antiherpesvirus agent both famciclovir and penciclovir are being evaluated in clinical studies this review covers the conversion of 1 jcm author of.

Antiviral Nucleoside and Nucleotide Analogs A ISSN: (Print) Review article / JAPR ISSN: (Online) Mahmoud et al.,2 (2), 73 - Synthesis of Triazole‐Containing Furanosyl Nucleoside Analogues and Their Phosphate, Phosphoramidate or Phoshonate Derivatives as Potential Sugar Diphosphate or Nucleotide Mimetics.

ChemPlusChem85 (8), Novel Nucleoside Analogues: Oxidative and Reductive Approaches toward Synthesis of 2'-Fluoro Pyrimidine Nucleosides, having been approved in respect to style and intellectual content, is referred to you for judgment.

The search of non-nucleoside analogs is encouraged because of the myelotoxic effects of the nucleoside analogs (molecules that act like nucleosides in DNA synthesis) [18].

The widely used vasodilator and antiarrhythmic agents, hydralazine [38], and procainamide [39], have been demonstrated to be non-nucleoside analog DNMT inhibitors.

Due to the worldwide epidemic of acquired immunodeficiency syndrome (AIDS), the past ten years have witnessed a flurry of activity in the chemotherapy of viral diseases. Unprecedented scientific efforts have been made by scientists and clinicians to combat infections of human immunodeficiency virus.

The present review is focused on the description of synthesis and antiviral activities of both acyclic and carbocyclic nucleoside phosphonates, endowed with an antiviral potential.

Despite the outstanding results in antiviral therapy of acyclovir and azidothymidine, a major drawback concerning the use of nucleoside analogues (NA) is the retention of their stability following triphosphorylation within.

Acyclic nucleoside phosphonates possess unique antiviral and antineoplastic activities; however, their polar phosphonate moiety is associated with low ability to cross biological membranes.

We explored the potential of transdermal and topical delivery of 2,6-diaminopurine derivative cPr-PMEDAP. In vitro diffusion of cPr-PMEDAP was investigated using formulations at different pH and. Recently, a promising nucleoside analogue with broad-spectrum activity against CoVs has been identified.

This review will discuss progress made in the development of antiviral nucleoside and nucleotide analogues targeting viral RNA synthesis as effective therapeutics against CoV infections and propose promising strategies for combination therapy.

Largely in response to the AIDS epidemic, the amount of research directed toward the discovery of antiviral agents has greatly expanded.

This new volume focuses on the potential of nucleotides to exert potent in vivo antiviral effects. It presents the findings of an international group of scientists who are carrying out research at the forefront of the nucleotide drug design.

Compiles current tested and proven approaches to synthesize novel nucleoside analogues Featuring contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues.

Nucleotide Analogues as Antiviral Agents by John C. Martin,available at Book Depository with free delivery worldwide. A nucleotide analogue that would not depend on activation by nucleoside/nucleotide kinases whilst serving as a natural substrate mimic, would be of great interest.

for HIV-RT points to the potential of this approach for the design of direct reverse transcriptase inhibitors as potential anti-HIV agents. Figure 6. Open in new avoiding at. Keywords:Deaminases, Iminoribitols, N-ribosyltransferases, nucleoside analogues, transition-state analogues, transition-state theory.

Abstract: Transition-state analysis based on kinetic isotope effects and computational chemistry provides electrostatic potential maps to serve as blueprints for the design and chemical synthesis of transition.

The present review is focused on the description of synthesis and antiviral activities of both acyclic and carbocyclic nucleoside phosphonates, endowed with an antiviral potential. Nucleoside analog inhibitors have figured prominently in the search for effective antiviral agents.

14 Nucleoside analogs are synthetic, chemically modified nucleosides that mimic their physiological counterparts (endogenous nucleosides) and block cellular division or viral replication by impairment DNA/RNA synthesis or by inhibition of.The hemorrhagic fever virus (HFV) infections, including Lassa and Ebola, that we highlighted as potential targets for antiviral agents in 1 have essentially remained unchanged, and now, 27 years later, we are still awaiting the first antiviral drug(s) to be formally approved for the treatment of HFV infections.

The first antiviral compound ever to be reported to be effective in the.Since the development and introduction of solid phase oligonucleotide synthesis in the s several nucleoside and nucleotide analogs have been identified as potent antiviral drugs.

These compounds exhibit activities against poxviruses including variola, vaccinia, monkeypox, cowpox, molluscum contagiosum, and the orf virus.